GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs4803468 | 1 | rs10417997 | chr19:41902361 | B3GNT8 | chr19:41931265-41934635:- | -0.21 | -6.62 | 5.61E-11 | Height |
| BRCA | cis | rs8170 | 1 | rs10418154 | chr19:17386006 | ANKLE1 | chr19:17392454-17398454:+ | 0.21 | 5.88 | 5.55E-9 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| BRCA | cis | rs8170 | 1 | rs10418154 | chr19:17386006 | ANO8 | chr19:17434032-17445638:- | 0.14 | 3.46 | 0.000572 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| BRCA | cis | rs8170 | 1 | rs10418154 | chr19:17386006 | OCEL1 | chr19:17337055-17340027:+ | 0.15 | 4.6 | 4.75E-6 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| BRCA | cis | rs8170 | 1 | rs10418362 | chr19:17386107 | ANKLE1 | chr19:17392454-17398454:+ | 0.2 | 5.8 | 8.96E-9 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| BRCA | cis | rs8170 | 1 | rs10418362 | chr19:17386107 | ANO8 | chr19:17434032-17445638:- | 0.14 | 3.44 | 0.000595 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| BRCA | cis | rs8170 | 1 | rs10418362 | chr19:17386107 | OCEL1 | chr19:17337055-17340027:+ | 0.15 | 4.66 | 3.55E-6 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| BRCA | cis | rs3760982 | 1 | rs10421887 | chr19:44294849 | LYPD5 | chr19:44300080-44324808:- | 0.13 | 3.82 | 0.000142 | Breast cancer |
| BRCA | cis | rs3760982 | 1 | rs10421887 | chr19:44294849 | ZNF155 | chr19:44488355-44502477:+ | 0.14 | 3.83 | 0.000135 | Breast cancer |
| BRCA | cis | rs3760982 | 1 | rs10421887 | chr19:44294849 | ZNF404 | chr19:44376516-44384288:- | 0.22 | 6.12 | 1.27E-9 | Breast cancer |
| BRCA | cis | rs6583954 | 1 | rs1042194 | chr10:96495484 | HELLS | chr10:96305543-96361855:+ | 0.12 | 3.42 | 0.000641 | Migraine |
| BRCA | cis | rs4803468 | 1 | rs10422783 | chr19:41906436 | B3GNT8 | chr19:41931265-41934635:- | -0.24 | -7.27 | 6.87E-13 | Height |
| BRCA | cis | rs4803468 | 1 | rs10422956 | chr19:41901261 | B3GNT8 | chr19:41931265-41934635:- | -0.24 | -7.25 | 7.86E-13 | Height |
| BRCA | cis | rs4808801 | 1 | rs10425982 | chr19:18586519 | LRRC25 | chr19:18501955-18508421:- | -0.14 | -6.83 | 1.4E-11 | Breast cancer |
| BRCA | cis | rs10431058 | 1 | rs10431058 | chr11:107481518 | ALKBH8 | chr11:107373454-107436461:- | -0.11 | -3.56 | 0.000394 | Common traits (Other) |